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Grey's Anatomy - Season 10 - Sandra Oh leaving

ABC's Grey's Anatomy is losing one of its original and most beloved stars.

Sandra Oh has opted to exit the medical drama from Shonda Rhimes, The Hollywood Reporter has learned exclusively.

Oh has played prickly doctor Cristina Yang since the series premiered in 2005 and will exit ABC's top-rated drama following the completion of its upcoming 10th season. The actress, who was among the stars who signed new two-year deals in May 2012 to return to Grey's through season 10, instead will pursue other opportunities beyond the series.

"Creatively, I really feel like I gave it my all, and I feel ready to let her go," an emotional Oh tells THR. "It's such an interesting thing to play a character for so long and to actually get the sense that she wants to be let go as well. [Cristina] wants to be let go, and I am ready to let her go. We have to start the process, story-wise, for the Grey's writers to think of why she's going to go."

More at THR

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