The Walking Dead - Season 2 - Glen Mazzara Teases Possible Upcoming Bloodshed

Is there anyone at this point who isn't going to blame themselves for Dale's death? Carl had his hand in it, and Rick to a certain extent by bringing Randall back to the farm.
Glen Mazzara: All of them see themselves as guilty. If there's one person who can hold their head up, it's Andrea (Laurie Holden) because she stood by Dale's side when he was fighting for Randall's life. She had his back, and she's the one person who feels that she stood by him at the end.

Who's going to be the most affected by the loss of Dale's moral compass?
Mazzara: Shane. Rick (Andrew Lincoln) ends up trying to hold on to that last vestige of the pre-apocalyptic world, and he tries to hold on to that humanity and Shane sees that as utter failure. That's the final straw for Shane.

Is it safe to say that Rick will now second-guess Randall's death sentence?
Mazzara: I think he already has, yes.

Source: Full interview @ The Hollywood Reporter