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Grey’s Anatomy‘s Jo is a fiercely independent and outspoken woman who survived a tumultuous childhood before launching her career at Grey Sloan Memorial.

She’s also in love with a fellow doctor by the name of Alex Karev and is partial to updos.

Hmm… sound like anyone else we know?

Yes, Karev’s current squeeze shares a few things in common with his first love, Izzie, but, as Jo’s portrayer Camilla Luddington points out, the two characters are very different people — particularly when it comes to how they treat Alex.

“I feel like Alex can be more himself in front of Jo,” the actress tells TVLine. “She doesn’t see anything wrong with him. His hotheadedness is the same as hers. She accepts him. I almost see them as partners in crime.”

Case in point: Alex’s sad little apartment. “I feel like Izzie would’ve made it look all pretty,” Luddington offers. “It’s still a little bit trashy, and I can see Jo and Alex thinking that it looks nice. Like that’s nice for them. Like they made an effort to buy some crappy thing from CVS and put it in the corner and they’re ready to throw a party. But I think that’s what’s endearing about them.

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